Medical device approaches

ABSTRACT

A system and method for providing image guidance for planning approach paths for one or more medical devices at a target location. The system can receive a volumetric medical image, determine a density of content within the volumetric medical image, receive an indication of a target location within the volumetric medical image, identify obstructing objects within the volumetric medical image, and determine a plurality of pathways from an approach region of the volumetric medical image to the target location. The system can cause a display to concurrently display the volumetric medical image and a plurality of emplacements for one or more medical imaging devices.

CROSS-REFERENCE TO RELATED APPLICATION

This application is a continuation of U.S. patent application Ser. No.15/955,059, filed Apr. 17, 2018, which is a continuation of U.S. patentapplication Ser. No. 15/199,711, filed Jun. 30, 2016, which claims thebenefit of U.S. Provisional Application No. 62/195,676, filed Jul. 22,2015, each of which is incorporated by reference herein in its entiretyfor all purposes. Any and all applications for which a foreign ordomestic priority claim is identified in the Application Data Sheet asfiled with the present application are incorporated by reference under37 CFR 1.57 and made a part of this specification.

BACKGROUND

Image-guided surgery makes use of imaging to aid the surgeon to performmore effective or more accurate surgery.

BRIEF DESCRIPTION OF THE DRAWINGS

FIGS. 1A and 1B illustrate exemplary volumetric medical images forimage-guided medical procedures.

FIG. 2 illustrates a two-dimensional slice of a volumetric medical imagewith exemplary image scanning and needle approach paths.

FIG. 3 illustrates a three-dimensional volumetric medical image withexemplary image scanning and needle approach paths.

FIG. 4 is a flow diagram illustrative of an embodiment of a routineimplemented by the system to display medical device emplacements.

FIG. 5A is a diagram illustrating an embodiment of an environment formedical device approaches.

FIG. 5B is a diagram illustrating an embodiment of a rendering ofmedical device approaches on a head mounted display.

DETAILED DESCRIPTION

Implementations disclosed herein provide systems, methods, and apparatusfor guidance tasks related to pose and/or emplacement of medicaldevices. Certain embodiments pertain to systems for facilitatingvisualization of medical imaging device scanning approaches and/orneedle approaches for surgical applications. Visualization of medicaldevice poses and/or emplacements can allow a user to select a desirableneedle insertion point to minimize insertion or repositioning attempts.

Systems and methods described herein can be used to determine one ormore poses and/or emplacements of various medical devices. The term“emplacement” and the term “pose” as used herein are broad termsencompassing their plain and ordinary meanings and can refer to, withoutlimitation, position, orientation, the combination of position andorientation, or any other appropriate location information.

As discussed elsewhere herein, there are numerous types of volumetric or3D data that various embodiments of the guidance system herein candisplay. The term “volumetric medical image” is a broad term thatencompasses its ordinary and customary meaning, and includes, withoutlimitation any data in a volume or 3D space that can be displayed. Thevolumetric medical image can include, without limitation, one or more ofa CT scan, an MRI, other 3D intraoperative or preoperative imaging data,other volume data, segmented internal organs, segmented blood vessels,annotations, tumors, etc. Such data can include CT scans, MRI, PET, 3Dultrasound, and any of numerous other types of 3D data. In someembodiments, in order to display 3D data on a 2D interface, such as acomputer screen, or even a 3D interface, such as a head-mounted displayor other 3D display, a subset of the data is chosen to display. Thissubset of data can include axis-aligned slices, the entire volume, or asub-volume of the data. An inherent difficulty with image guidance isthe display of three dimensions of data on a two-dimensional screen or“dual eye” three-dimensional display. When displaying 3D data, such asCT scans, a system might only display a single plane, or show threeorthogonal planes separately on the screen. The data can also be shownas a volumetric ‘block’ of data, as shown in FIG. 3.

FIGS. 1A and 1B illustrate exemplary volumetric medical images 100 forimage-guided medical procedures. The image 100 can be obtained based onany medical imaging technology as described herein, such as ultrasound,CT scan, MRI, open-magnet MRI, optical coherence tomography, positronemission tomography (“PET”) scans, fluoroscopy, ultrasound, or otherpreoperative, or intraoperative 2D or 3D anatomical imaging data. Theimage 100 can include multiple planes or slices 110 of image data. Insome aspects, the volumetric medical image 100 can be obtained as aplurality of slices 110 from an imaging device configured to performmultiple 2D scans, or can be obtained as 3D volume data from an imagingdevice configured to generate 3D data. Where volumetric imagery isobtained from 2D scans, the planes or slices 110 can be the slices asobtained from the 2D scans, or they can be modified and/or generated tobe, for example, parallel to the plane of a region of interest.

As depicted in FIG. 1B, a plane or slice 110 of the volumetric medicalimage 100 can include a cross-sectional view of a portion of a subject120. In various embodiments, the location and orientation of the planeor slice 110 can be selected automatically based on detected structureswithin the volumetric medical image 100, or can be selected manually bya user. For example, the location and orientation can be selected so asto provide a cross-sectional view of a target structure 130, such as alesion, tumor, or other structure.

In some embodiments, a region of interest 140 can be selected within aplane or slice 110. The region of interest 140 can be selectedautomatically or by a user, for example, based on a location of anemplacement sensor associated with a medical device (e.g., an ultrasoundprobe) manipulated by the user. In some implementations, the system canutilize and/or display imagery associated with the medical device (e.g.,ultrasound image data obtained from an ultrasound probe) in addition to(e.g., superimposed upon) the volumetric image data. The data shown inthe region of interest can be any appropriate visualizable medical data,not limited to ultrasound or CT data. Further, the data displayedoutside of the region of interest can be any visualizable medical data,and can even be from the same data set as the data shown in the regionof interest. For example, MRI data can be shown in fading planes outsideof the region of interest and in focus (and visualizable through atunnel) inside the region of interest. Further, annotation can bedisplayed along with the rendering of the visualizable medical datainside and/or outside of the region of interest. In this manner, a usercan see the annotations in the context of the visualizable medical data.

In various embodiments, more than one set of visualizable medical datacan be rendered. Each one can be rendered in a different manner. Forexample, they can be rendered with different transparencies,brightnesses, contrast, colors, etc. Further, one or more can berendered with a different transparency, brightness, contrast or color asdistance from the region of interest increases. For example, brightnesscan decrease and/or transparency can increase further from the region ofinterest 140.

FIG. 2 illustrates a 2D slice 200 of a volumetric medical image withexemplary image scanning and needle approach paths as determined by aguidance system. The exemplary slice 200 depicted in FIG. 2 includes across-sectional image of a torso of a patient, including sections ofskin 202, bone 204, gas 206, and other internal tissues 208, as well asa target structure 210 (non-limiting examples: a lesion, tumor, or othertarget). Also depicted are a suggested scanning path 212 for anultrasound probe and suggested approach paths 216 for a needle 218 orother invasive medical device.

The target structures 210 can be identified in a variety of ways. Insome embodiments, the guidance system can allow a user to mark a targetby interacting with the display of the volumetric medical image. Forexample, consider a procedure where the doctor is using the guidancesystem with an ablation needle 218 and an ultrasound probe 214. Thedoctor can mark the target structure 210 by pressing a button on akeyboard or mouse, touching a screen, pointing with a medical device,gesturing or issuing a verbal command, or with any other appropriatemethod, as described in greater detail in U.S. application. Ser. No.14/166,179, entitled, SYSTEMS, METHODS, APPARATUSES, ANDCOMPUTER-READABLE MEDIA FOR IMAGE MANAGEMENT IN IMAGE-GUIDED MEDICALPROCEDURES, and Ser. No. 13/014,596, entitled, IMAGE ANNOTATION INIMAGE-GUIDED MEDICAL PROCEDURES, each of which is incorporated herein byreference in its entirety.

In some embodiments, the system can detect the target structure 210within an image stream obtained from an imaging device manipulated bythe user (e.g., an ultrasound probe 214). In certain embodiments, thelocation of the target structure 210 can be marked at the point where aneedle 218 intersects with the ultrasound image plane, where theneedle's projection intersects with the ultrasound image plane, or anyother appropriate relationship (such as at the location of the tip ofthe needle). For example, when a physician identifies a target structure210 within the ultrasound image, she can point to it using the needle218 even if the needle 218 is outside the body of the patient. Thephysician (or assistant) can press, for example, a button or foot pedal,which informs the image guidance system to store the 3D position of thistarget structure 210. In some embodiments, the target structure 210 canbe identified based at least in part on the amount of time the physicianspends observing an object or the amount of time that a medical device,or corresponding emplacement sensor, is located at a particularemplacement. For example, if a lesion or other abnormal structure isdetected within the ultrasound image, and the physician keeps the probe214 in the same location for a threshold time period (e.g., 3 seconds, 5seconds, 10 seconds, 15 seconds, or longer), the guidance system candetermine that the object is a target structure 210 and store itslocation.

In certain embodiments, the system can identify multiple targetstructures 210. For example, physicians, during some liver ablationprocedures or other procedures, can manage fifteen target structures210, or even more. The guidance system can store and display any numberof target structures 210 concurrently. If there is more than one targetstructure 210 in view, the image guidance system can display a number orother indicator next to each one (not pictured). In some embodiments, inorder to reduce visual clutter if there are many target structures 210,those target structures 210 which are closer to the ultrasound imageplane can be drawn more saliently or vividly (with more bold color andthicker lines) while the points that are far away are drawn lesssaliently (more transparent, blurred, muted colors, etc.).

In addition, to identifying a target structure, the system can analyzethe various types of tissue within the medical image to determine anapproach path for the medical device. For example, ultrasound wavesemitted by an ultrasound probe 214 may be able to travel through softtissues 208 of a patient, but can be blocked or scattered by densertissues such as bone 204, or by regions of lower density, such as gas208. An ablation needle 218 may be able to travel through soft tissues208 and/or regions of gas 208, but may be unable to travel through bone204. In addition, needle approach paths can be chosen so as to avoidcritical or delicate regions such as blood vessels or vital organs (notshown), even though such regions do not present an obstacle toultrasound scanning.

Thus, when a 2D slice 200 is obtained, the guidance system can analyzethe image to determine the tissue type or density of various regions ofthe image. In some embodiments, the guidance system can analyze theslice 200 based on an intensity of some or all pixels or voxels withinthe slice 200. The system can determine a radiodensity or intensity ofvoxels based on the Hounsfield unit (HU) scale or other suitable scale.For example, an intensity of greater than 700 HU can indicate bone,while an intensity of between −1000 HU and −350 HU can indicateintestinal gas. However, it will be understood that different imagingdevices can output different HU for different types of tissue or can usedifferent scales for intensity of voxels.

In some embodiments, the system can analyze the intensity level for eachvoxel of the medical image to determine the tissue type and/or objectdensity. In certain embodiments, the system can use edge detection toidentify objects, for example, to identify the location of skin 202within the image slice 200. In some aspects, the system can use known HUvalues of critical or delicate regions (e.g., large blood vessels,heart, etc.) to identify the critical or delicate regions. Furthermore,in certain embodiments, such as with medical images involving the chestor abdomen of a patient, the system can analyze one or more image slices200 taken at different parts of the breathing cycle. In this way, thesystem can determine the emplacement of the objects within the imageslices at different parts of the breathing cycle and to identifydeformations of the objects caused by breathing. It will be understoodthat the system can use other scales or measurements to identify theobjects in the medical image, such as, but not limited to, manual orautomatic segmentation, annotation, as described in greater detail inU.S. application Ser. No. 13/014,596, entitled, IMAGE ANNOTATION INIMAGE-GUIDED MEDICAL PROCEDURES, previously incorporated herein byreference, etc.

In addition to analyzing the content of the medical image, the systemcan determine one or more medical device approach paths 216 to thetarget structure 210 from an approach region. The approach region cancorrespond to a surface or perimeter of the medical image and/or adesired start point, surface, or perimeter within the medical image. Forexample, the system can determine and display paths to the targetstructure from the surface of the medical image and/or from a particularstructure within the medical image, such as the skin, an intestine, etc.In certain embodiments, to identify medical device approach paths 216 tothe target structure 210, the system can analyze a plurality of pathsbetween the target structure 210 and the approach region of the medicalimage.

In some cases, the system can use ray tracing or ray casting to identifypaths to the target structure from the approach region of the image. Forexample, the system can analyze voxels along a particular path toidentify paths between the target structure 210 and the approach region.

In some embodiments, the system can use one or more rendered images toidentify paths to the target structure. For example, the system canrender one more images from the perspective of the target to theapproach region. In some embodiments, the system can treat the target asa point-of-view location and capture the voxels located between thetarget and the approach region, similar to a camera taking a picture. Incertain embodiments, the volume of the captured voxels can generallycorrespond to a trapezoid, cone, frustum, or other shape.

In certain embodiments, the one or more images can be from differentangles with respect to the target. As a non-limiting example, if theapproach region is the surface of the 3D volume and the target islocated within the 3D volume, the system can render six images (each onefrom the perspective of a different side of a cube corresponding to thetarget). It will be understood that fewer or more images can be renderedfrom different perspectives, as desired.

The system can render the captured images (or captured voxels). As partof the rendering process, the system can map the captured volume ofvoxels or imaged volume to an image area or region. In addition, thesystem can identify how to treat the different voxels during therendering process. For example, the system can average the voxels thatare to be located on a point of the image area, use the minimum ormaximum voxel for the point of the image area, etc. In certainembodiments, the system can identify voxels that do not satisfy adensity threshold (or otherwise not to be used for a medical deviceapproach), as described in greater detail below, to be rendereddifferently than voxels that satisfy the density threshold. For example,if any one of the voxels that are to be mapped to a location in theimage area do not satisfy the density threshold, the system can colorcode the location, such as by whiting or blacking it out, etc.

The one or more rendered images can be applied or mapped to the approachregion of the 3D volume for viewing. With continued reference to theexample, the system can map the one or more images to the surface of the3D volume. Accordingly, a user can view the images on the approachregion. In some embodiments, the system can also analyze the renderedimages (non-limiting examples: using voxel intensities, edge detection,etc.) to identify locations in the rendered image in which the approachregion is visible. The identification of the approach region within theimage can indicate a direct path between the approach region and thetarget structure 210.

In certain embodiments, the system can analyze the image slice 200 alonga series of circular paths of increasing or decreasing radius andcentered on the target structure 210 (e.g., from the target structure210 outward, or from the approach region). For example, the system cananalyze the voxels within a sphere and then expand the sphere andanalyze voxels within the expanded sphere. Analyzing a series ofcircular paths can be efficient, as angular segments of a circle thatare deemed unacceptable for an approach path (e.g., due to the presenceof bone) can be eliminated and the same angular regions can be omittedfrom the analysis of later circular paths, reducing processing time.

In analyzing the various paths between the target structure 210 to theapproach region, the system can apply one or more criteria to identifyone or more medical device approaches 216. For example, the system canuse a density threshold, characteristics of a medical device, such aslength, width, thickness, diameter, scan length, scan width, numbertransducer crystals, etc., to identify one or more medical deviceapproaches.

In certain cases, the system can use characteristics of the medicaldevice to determine the medical device approach. The medical device canbe an invasive medical device, such as, but not limited to, biopsyneedles, ablation needles, surgical needles, nerve-block needles, orother needles, electrocautery device, catheters, stents, laparoscopes orlaparoscopic cameras, ultrasound transducers, or other instruments thatenter a part of the body, or a non-invasive medical device that does notenter the body, such as, but not limited to, ultrasound transducers,probes, other external imaging devices, or other external devices, etc.The medical devices can also include medical imaging devices thatprovide or aid in the selection or generation of medical images fordisplay. In some embodiments, the medical imaging device can be anydevice that is used to select a particular medical image for display orgenerate medical images. The medical imaging devices can includeinvasive medical devices, such as laparoscopic cameras or invasiveultrasound transducers, and non-invasive medical devices, such asexternal ultrasound transducers.

Depending on the medical device used, the medical device approach can bedifferent. For example, each medical device can have unique dimensions,such as width, length, and/or thickness. Similarly, medical imagingdevices can have different imaging depths, widths and/or thicknesses. Inaddition, medical imaging devices can use different scan frequencies,each of which can affect which tissue can be imaged. The system can usethe various characteristics to determine the medical device approach.

In some embodiments, such as for invasive medical devices, the systemcan use the medical device's physical characteristics, such as itshardness or ability to pass through an object, deformability, curvature,length, width, thickness, and/or diameter to determine the medicaldevice approach. Each invasive medical device can have its own physicalcharacteristics that the system can use to determine the medical deviceapproach. For example, the system can determine more medical deviceapproaches for invasive medical devices that are longer, thinner, aremore deformable, or have a smaller diameter. In some cases, thediameter, deformability, or thickness of the medical device can bedifferent along its longitudinal axis. In such cases, the system can usethe different thicknesses or deformability and location along themedical device axis to identify the medical device approaches.

With reference to FIG. 2, in some implementations, the system caneliminate paths 216 that pass through a region of bone 204, or otherregion through which the needle 218 is unable to pass. Similarly, thesystem can eliminate paths for the needle 218 that pass through a vitalorgan or a large blood vessel (not shown). In certain embodiments, thesystem can have information regarding the length of the needle 218, andcan determine a maximum approach path length based at least in part onthe length of the needle 218 and/or maximum reach of the needle 218. Thesystem can exclude approach paths in which the distance from theapproach region to the target structure 210 is longer than maximumapproach length. In some embodiments, the system can include approachpaths 216 that are wide and/or thick enough for the needle 218 to passthrough, based on a known width and/or thickness of the needle 218.

In certain embodiments, such as for medical imaging devices, the systemcan use the imaging characteristics of the medical imaging device, suchas, but not limited to, number of imaging sensors, number of transducercrystals, imaging frequency, imaging depth, resolution, fade, imagingwidth and/or imaging thickness to determine the medical device approach.In some cases, such as for invasive medical imaging devices, the systemcan also use the physical characteristics of the medical imaging device.In certain circumstances, the system can use the physicalcharacteristics of a non-invasive medical imaging as well.

Similar to physical characteristics, each medical imaging device canhave unique imaging characteristics that the system can use to determinethe medical device approach. In certain embodiments, the system candetermine more medical device approaches for medical imaging devicesthat have a larger imaging depth, larger imaging width, more imagingsensors, more transducer crystals, better resolution, less fade, orlower imaging frequency. For example, medical imaging devices with alarger imaging depth or width, more imaging sensors or more transducerscan capture a larger image cross-section, which can enable the system toidentify more potential paths. Similarly, the system can identify moremedical device paths for medical imaging devices that have betterresolution or fade less based on the distance from the imager, etc.

In addition, in some cases, imaging devices may unable to penetratecertain tissue depending on the frequency used. For example, manyultrasound transducers are unable to penetrate bone or gas and opticalimage sensors cannot penetrate tissue. Accordingly, the system can usethe scan frequency or imaging type to identify medical deviceapproaches. In addition, as described in greater detail above withreference to invasive medical devices, the physical characteristics of amedical imaging device can affect the number of medical deviceapproaches identified by the system.

With continued reference to the embodiments illustrated in FIG. 2, thesystem can eliminate paths that pass through regions of gas 206 or bone204 because the ultrasound probe 214 cannot penetrate the gas 206 orbone 204. The system 204 can use the imaging dimensions of theultrasound probe to determine medical device paths 212 as well. Forexample, the ultrasound probe 214 can include a linear array ofultrasound crystals, each crystal configured for imaging along a path.The system can determine acceptable ultrasound scanning paths 212 wherethe unobstructed path has a 2D or 3D width of a threshold number ofcrystals.

In certain embodiments, the threshold number of crystals can be based ona number of crystals that have an unobstructed path to the targetstructure 210 and/or a number of crystals of the ultrasound probe 214.For example, the threshold number of crystals can be 25% or 50% of thetotal number of crystals of the ultrasound probe 214, and/or can be 1,3, 5, 10, 15, or more crystals. In addition, the system can use theimage depth of the ultrasound probe 214 determine the medical deviceapproach paths 216. For example, the system can eliminate paths to thetarget structure 210 that are longer than the image depth of theultrasound probe 210.

In some cases, the system can use a density threshold to identify themedical device approaches. As mentioned above, the density threshold canbe based on the Hounsfield unit scale or similar scale, and cancorrespond to a minimum density, maximum density, or range of densities.In some embodiments, the system can identify objects and/or voxels thatdo not satisfy the density threshold (or are otherwise not to be usedfor a medical device approach) as obstructing objects. In certainembodiments, the system can exclude paths that intersect withobstructing objects. In addition, in some cases, the system can identifyvoxels or objects that have been annotated as not satisfying the densitythreshold or as obstructing objects.

In some embodiments, the density threshold can be static. For example,the system can identify objects having a density equal to or greaterthan bone as not satisfying the density threshold, irrespective of themedical device. In certain embodiments, such as when the density ofcritical tissue, such as heart tissue is known, the system can identifyobjects having the same density as the critical tissue as not satisfyingthe density threshold.

In certain embodiments, the density threshold can be based at least inpart on a characteristic of the medical device. For example, gas withinthe image can satisfy the density threshold for a needle, but may notsatisfy the threshold for an ultrasound device.

In some cases, the system can identify one or more semi-direct pathsfrom the target structure 210 to the approach region. In certainembodiments, a semi-direct path may become available if a portion of theapproach region or patient is deformed. For example, if a physicianwants to access a portion of a patient under the rib cage, no directpath may be available. However, by compressing the abdomen or at adifferent time of the breathing cycling, a path may become available.Accordingly, in certain embodiments, the system can identify semi-directmedical device approaches based at least in part on a deformation of theapproach region of an image. In some cases, the system can apply aflexibility factor to the approach region of the image. The flexibilityfactor can indicate a margin by which the approach region can be flexed.For example, the flexibility factor can indicate that the approachregion can be flexed by 1-5 cm or by a percentage of the width or lengthof the image. Using the flexibility factor and other information asdescribe above, the system can identify one or more semi-direct medicaldevice approaches.

Based on the identified medical device approaches the system canidentify and display locations at the approach region for emplacing themedical device. In certain embodiments, the system can identify anddisplay a particular emplacement for the medical device. For example,the system can highlight a region corresponding to the dimensions of themedical device. As another non-limiting example, based on two needleapproach paths 216 determined to be acceptable, the system can displayemplacements such as by displaying images of needles 218 along theacceptable paths 216, and/or by displaying highlighted or otherwisedistinguishing portions of the approach region. Similarly, the systemcan display one or more ultrasound probe emplacements such as bydisplaying an image of an ultrasound probe 214, by displaying a scanningregion or path 212, and/or by displaying a highlighted or otherwisedistinguishable portion of the approach region.

In addition, in certain embodiments, the system can highlight theportions of the medical image area or volume that satisfy the densitythreshold and/or that can be used as part of a medical device approach.For example, the objects and/or voxels throughout the medical image areaor volume that satisfy the density threshold can be highlighted,displayed in a particular color, or brought into focus. Similarly, theobjects and/or voxels that do not satisfy the density threshold can befaded, taken out of focus, displayed in a different color etc.

In some embodiments, the system can track the location of a medicaldevice and identify and display one or more medical device approachesbased at least in part on the determined location of the medical device.The medical device approaches can be for the tracked medical deviceand/or for another medical device. For example, if the system istracking a medical imaging device, it can display medical deviceapproaches for the medical imaging device and/or for another medicaldevice, such as an invasive medical device. In certain embodiments, thesystem can use the determined location of the medical device to displayand/or highlight the medical device approaches that are nearest to themedical device. For example, if the system identifies six medical deviceapproaches, it can use the determined location of the medical device todisplay or highlight the three medical device approaches that areclosest to the determined location of the medical device.

Similar systems and methods can be applied with 3D volumetric images.FIG. 3 illustrates a 3D volumetric medical image 300 with exemplaryimage scanning and needle approach paths. The exemplary image 300depicted in FIG. 3 includes a volume 302 containing a target structure304, skin 306, bone 308, and other internal tissue 310. As described ingreater detail with reference to FIG. 2, the system can determineapproach paths, poses, and/or emplacements for medical devices such asan ultrasound probe 312 and a needle 314, or other medical device. Insome aspects, acceptable, desirable, and/or suggested approach paths canbe selected in a 3D volume based on the same or similar criteria asthose discussed above with reference to FIG. 2. For example, ultrasoundscanning paths can be selected so as to avoid regions of gas or bone 308and/or based on imaging characteristics of the ultrasound probe 312.Needle approach paths can be selected so as to avoid regions of bone 308or delicate structures, and/or based on the length of the needle 314.

Similar to the 2D system described with reference to FIG. 2, the systemcan use a variety of techniques to analyze and determine acceptablemedical device approaches. For example, the system can utilize raytracing, projective texture mapping, edge detection, one or morerendered images, etc., as described above by analyzing a plurality ofdirect or semi-direct paths between the approach region and the targetstructure 304. Some implementations can analyze the volume 302 along aplurality of spherical surfaces of increasing or decreasing radius,similar to the circular paths analyzed in 2D systems described above.Suggested emplacements 316 can then be displayed within the 3Dvolumetric medical image 300 for the reference of the physician.

When displaying 3D volumetric data, voxels in front (closer to thepoint-of-view location) can obscure the voxels behind them. In someinstances, this can occlude information that can be important frompreoperative 3D data. One way to address this is to allow the doctor toview the data as 2D slices 318, in cross section, etc., as described ingreater detail in U.S. application Ser. No. 14/166,179, entitled,SYSTEMS, METHODS, APPARATUSES, AND COMPUTER-READABLE MEDIA FOR IMAGEMANAGEMENT IN IMAGE-GUIDED MEDICAL PROCEDURES, incorporated by referenceherein in its entirety. For example, a 2D slice 318 can be displayedbased on a location of a medical device such as an ultrasound probe 312,with the location of the probe 312 determined based on data receivedfrom one or more emplacement sensors.

Moreover, the determined location of the probe 312 can be used to selectsuggested emplacements for a second medical device. For example, wherethe emplacement data indicates the location of an ultrasound probe 312imaging the target structure 304, the guidance system can select one ormore needle emplacements 316 near the location of the probe 312 (e.g.,to facilitate the physician's simultaneous manipulation of the probe 312and needle 314). In some embodiments, a previously obtained, real-time,or near real-time medical image (e.g., an ultrasound image obtained fromthe probe 312) can be superimposed on the 2D slice 318. In someembodiments, to enhance the visibility of the 2D slice 318, the 2D slice318 can be displayed with increased brightness relative to thesurrounding 3D volumetric image 300, or the surrounding 3D volumetricimage 300 can be displayed with partial transparency or out of focus.

FIG. 4 is a flow diagram illustrative of an embodiment of a routine 400implemented to display medical device emplacements. One skilled in therelevant art will appreciate that the elements outlined for routine 400can be implemented by one or more computing devices/components that areassociated with the systems described herein. Further, it will beunderstood that the various blocks described herein with reference toFIG. 4 can be implemented in a variety of orders. For example, someblocks can be implemented concurrently or in a different order asdesired. For example, the system can perform blocks 420 and 430concurrently and/or implement them in a different order.

At block 410, a volumetric medical image is received. As describedelsewhere herein, the volumetric medical image can be obtained from anyof various medical imaging technologies, including without limitationultrasound, CT scan, MRI, open-magnet MRI, optical coherence tomography,PET scans, fluoroscopy, ultrasound, or other preoperative orintraoperative 2D or 3D anatomical imaging data. The volumetric medicalimage can be received as a single set of 3D volumetric data, or can bereceived as a plurality of 2D slices as described with reference toFIGS. 1A-B. In some embodiments, a volumetric medical image received asa single set of 3D volumetric data can be converted into a plurality of2D image slices, and/or a volumetric medical image received as aplurality of 2D slices can be converted to a 3D volume as desired.

At block 420, the density of content within the volumetric medical imagecan be determined. As described in greater detail above, in someembodiments, the density of content can be determined based at least inpart on an intensity value of voxels associated with the content withinthe volumetric medical image. For example, the density of content can bedetermined using a Hounsfield unit scale or other suitable scale fordetermining a mass density based on an image intensity.

At block 430, an indication can be received of a target location withinthe volumetric medical image. As described in greater detail above, insome embodiments, the indication can be received from a human user, suchas a physician, can be received based on an input by the user, such as akeystroke or button press, or the like, and/or can be determined by thesystem, for example, based on a computer analysis of a region within themedical image, a detected reaction of a user, an amount of time amedical device is located at a particular emplacement, etc. In anotherexample, the target location can be determined based on a real-timemedical image. For example, as depicted in FIG. 3, the target locationcan be determined based on a structure being scanned by a user with anultrasound probe. The target location can be determined based on thecombination of the location of the target structure within the real-timeultrasound image and the determined emplacement of the emplacementsensor associated with the ultrasound probe. In various embodiments, oneor more target locations can be selected and/or stored.

At block 440, the system can identify one or more obstructing objectswithin the volumetric medical image. In some embodiments, the system canidentify the obstructing objects based at least in part on thedetermined density of content within the volumetric medical image, orotherwise identified as not to be used for a medical device approach. Incertain embodiments, obstructing objects can be determined based onregions within the volumetric medical image having a density that doesnot satisfy a density threshold. As described previously, the densitythreshold can be a minimum density, maximum density or range ofdensities. For example, the system can identify a region having adensity approximately equal to the density of bone as an obstructingobject.

In some embodiments, the density threshold can be based at least in parton one or more imaging characteristics of a medical imaging device. Forexample, the density threshold can be based at least in part on a scanfrequency of the medical imaging device. The maximum density of objectsthrough which waves and/or radiation emitted by a medical imaging devicecan pass can vary based on the frequency of the waves and/or radiation(e.g., a scan frequency). Thus, the density threshold can be determinedbased on the known scan frequency of the medical imaging device. Inanother example, the density threshold can be determined based on thetype of medical device (e.g., whether the device is an intrusive device,medical imaging device, or other type of medical device). In someaspects, the density threshold can include a single threshold, or caninclude a range of densities. For example, a density threshold for anultrasound imaging device can include the range between −350 HU and 700HU, so as to exclude regions of intestinal gas, air, and bone.

At block 450, one or more pathways can be determined from an approachregion of the volumetric medical image to the target location. In someembodiments, the pathways can be identified based on pathways from theapproach region of the medical image to the target that do not intersector pass through an obstructing object. In certain embodiments, thesystem can identify the pathways based on pathways from the approachregion of the medical image to the target that intersect or pass throughat least two image slices. The pathways can be determined based on themethods described elsewhere herein, such as ray tracing, projectivetexture mapping, one or more rendered images, analysis of circularpaths, analysis of spherical surfaces, or other methods.

As described in greater detail above, in some implementations, the oneor more pathways can be determined based at least in part oncharacteristics of the medical device, such as threshold quantity oftransducing elements at a particular emplacement of a medical imagingdevice each having a direct path to the target location that does notpass through the identified obstructing objects, other imagingcharacteristics of the medical device, and/or physical characteristicsof the medical device. For example, for an ultrasound probe having aplurality of detecting crystals disposed in a linear array with knownspacing, the plurality of pathways can be selected to be wide enoughthat at least 1, 3, 5, 10, 15, or more crystals of the ultrasound probewill have a direct path to the target location clear of obstructingobjects, or a certain percentage of the ultrasound probe's crystals willhave a direct path to the target location.

As described previously, in some cases, the system can identify the oneor more pathways based on a tracked location of a medical device. Incertain embodiments, the pathways identified can be for the trackedmedical device and/or for another medical device.

At block 460, the system can cause a display to concurrently display thevolumetric medical image and a plurality of emplacements on the approachregion of the volumetric medical image for emplacements of one or moremedical devices. Emplacements can be determined based at least in parton the determined plurality of direct pathways. For example, anemplacement for a medical imaging device can be determined as a locationalong the approach region of the volumetric medical image where theimage scanning path of the medical imaging device includes one of thedetermined plurality of direct pathways within the volumetric medicalimage. In some embodiments, the plurality of emplacements can bedisplayed based at least in part on a determined emplacement of anemplacement sensor based on emplacement data received from theemplacement sensor. For example, the emplacement sensor can beassociated with a medical device such as an ultrasound probe.

In some embodiments, the system described herein can be implemented inconjunction with and/or as part of a guidance system, as described belowwith reference to FIGS. 5A, 5B, and as described in greater detail inU.S. application. No. TBD, filed concurrently herewith, entitled, LOUPEDISPLAY (Attorney Docket: INOPT.061A).

FIG. 5A is a diagram illustrating an embodiment of an environment 500for image-guided medical device approaches. In the illustratedembodiment, the environment 500 includes a display 502 displaying animage 550, an image guidance unit 504, a position sensing unit 506, asurgical system 508, imager 510, medical devices 512, 514, a patient516, a stand 518, and a table 520. In some embodiments, an imageguidance system 501 can include any one or any combination of thedisplay 502, the image guidance unit 504, the position sensing unit 506,the surgical system 508, the imager 510, the medical devices 512, 514,the stand 518, and/or the table 520.

In some embodiments, the position sensing unit 506 can track medicaldevices 512, 514 within an area or volume, which can also be referred toas a tracked region or position sensing region, and provide data to theimage guidance unit 504.

Although only two medical devices 512, 514 are shown in FIG. 5A, it willbe understood that additional medical devices can be tracked andassociated data can be provided to the image guidance unit 504. Theimage guidance unit 504 can process or combine the data and show imageguidance data on display 502. This image guidance data can be used by ahealthcare provider to guide a procedure and improve care. The imageguidance data can also be used by the system to identify the medicaldevice approaches described above.

There are numerous other possible embodiments of system 501. Forexample, many of the depicted components can be joined together to forma single component and can be implemented in a single computer ormachine. Further, additional position sensing units can be used inconjunction with position sensing unit 506 to track relevant medicaldevices 512, 514, as discussed in more detail below. Additional imagers510 can be included, and combined imaging data from the multiple imagers510 can be processed by image guidance unit 504 and shown on display502. Additionally, two or more surgical systems 508 can be used.

Information about and from multiple surgical systems 508 and attachedmedical devices 512 (and additional medical devices not shown) can beprocessed by image guidance unit 504 and shown on display 502. These andother possible embodiments are discussed in more detail below. It willbe understood that any combination of the display objects, imageguidance cues, etc., described herein can be displayed concurrently, orsimultaneously. Further, reference to displaying objects “concurrently”and/or “simultaneously” is to be interpreted broadly and may refer todisplaying objects in such a way that to a human observer the objectsare visible at the same time.

Imager 510 can be communicatively coupled to image guidance unit 504. Insome embodiments, imager 510 can be coupled to a second display unit(not shown). The second display unit can display imaging data fromimager 510. The imaging data displayed on display 502 and displayed onsecond display unit can be the same or different. In some embodiments,the imager 510 can be an ultrasound machine 510, the medical device 514can be a movable imaging unit, such as an ultrasound transducer 514 orultrasound probe 514, and the second display unit can be a displayassociated with the ultrasound machine 510 that displays the ultrasoundimages from the ultrasound machine 510. In some embodiments, a movableimaging unit 514 can be communicatively coupled to image guidance unit504. The movable imaging unit 514 can be useful for allowing a user toindicate what portions of a first set of imaging data are to bedisplayed. For example, the movable imaging unit 514 can be anultrasound transducer 514, a needle or other medical device, forexample, and can be used by a user to indicate what portions of imagingdata, such as an intraoperative or preoperative CT scan, to show on adisplay 502 as image 550. The movable imaging unit 514 can also be usedto identify medical device approaches for the moveable imaging unit 514and/or for the medical device 512. Further, in some embodiments, therecan be a third set of intraoperative or preoperative imaging data thatcan be displayed with the first set of imaging data.

In some embodiments, a navigation system 501 comprises a display 502 anda position sensing unit 506 communicatively coupled to image guidanceunit 504. In some embodiments, position sensing unit 506, display 502,and image guidance unit 504 are coupled to the stand 518. Image guidanceunit 504 can be used to produce images 550 that are displayed on display502. The images 550 produced on display 502 by the image guidance unit504 can be determined based on ultrasound or other visual images fromthe first medical device 512 and second medical device 514.

In the illustrated embodiment, the image 550 can include the volumetricmedical image 300 described above in greater detail. In the image 550,some or all of the display objects can be displayed as 3D objects.Furthermore, the display objects in the image 550 can be displayed in aperspective based at least in part on a point-of-view location. Moremedical devices can be added to the system 501 as desired. For example,the system 501 can include an ultrasound probe, ablation needle,laparoscopic camera, stapler, cauterizer, scalpel and/or any othermedical device or medical device, and the system 501 can determine amedical device approach for any one or more of the medical devices. Thesystem 501 can also process and/or display collected data, such aspreoperative CT scans, X-Rays, MRIs, laser scanned 3D surfaces etc.

In some embodiments, the imaging data obtained from one or both ofmedical devices 512 and 514 can include other modalities such as a CTscan, MRI, open-magnet MRI, optical coherence tomography (“OCT”),positron emission tomography (“PET”) scans, fluoroscopy, ultrasound, orother preoperative, or intraoperative 6D or 3D anatomical imaging data.In some embodiments, medical devices 512 and 514 can also be scalpels,implantable hardware, or any other device used in surgery. Anyappropriate surgical system 508 or imager 510 can be communicativelycoupled to the corresponding medical instruments 512 and 514.

The medical devices 512, 514 can be communicatively coupled to theposition sensing unit 506 (non-limiting example: sensors embedded orcoupled to the medical devices 512, 514 can be communicatively coupledwith the position sensing unit 506). The position sensing unit 506 canbe part of imager 510 or it can be separate. The position sensing unit506 can be used to determine the emplacement of first medical device 512and/or the second medical device 514. In some embodiments, the positionsensing unit 506 can include a magnetic tracker and/or one or moremagnetic coils can be coupled to medical devices 512 and/or 514. In someembodiments, the position sensing unit 506 can include an opticaltracker and/or one or more visually-detectable fiducials can be coupledto medical devices 512 and/or 514. In some embodiments, the positionsensing unit 506 can be located below the patient. In such embodiments,the position sensing unit 506 can be located on or below the table 520.For example, in embodiments where the position sensing unit 506 is amagnetic tracker, it can be mounted below the surgical table 520. Suchan arrangement can be useful when the tracking volume of the positionsensing unit 506 is dependent on the location of the position sensingunit 506, as with many magnetic trackers. In some embodiments, magnetictracking coils can be mounted in or on the medical devices 512 and 514.

In some embodiments, the position sensing unit can determine one or morex, y, z coordinates and/or the quaternions (non-limiting examples: yaw,pitch, and/or roll) of tracking sensors associated with one or more ofthe medical devices 512, 514. In certain cases, the position sensingunit can determine the one or more x, y, z coordinates of the trackingsensors with respect to a position sensing coordinate system, asdescribed in greater detail below. In some embodiments, the positionsensing unit 506 can be an electromagnetic measurement system(non-limiting example: NDI Aurora system) using sensor coils fortracking sensors attached to the first and/or second medical devices512, 514. In some embodiments, the position sensing unit 506 can be anoptical 3D tracking system using fiducials for tracking sensors. Suchoptical 3D tracking systems can include the NDI Polaris Spectra, Vicra,Certus, PhaseSpace IMPULSE, Vicon MX, InterSense IS-900, NaturalPointOptiTrack, Polhemus FastTrak, IsoTrak, or Claron MicronTracker2. In someembodiments, the position sensing unit 506 can each be an inertial 3Dtracking system comprising a compass, accelerometer, tilt sensor, and/orgyro, such as the InterSense InertiaCube or the Nintendo Wii controller,mechanical tracking system, camera-based tracking system, radar-basedtracking system, etc. In some embodiments, the position sensing unit 506can be attached to or affixed on the corresponding medical device 512and 514.

In some embodiments, the position sensing units 506, can include sensingdevices such as the HiBall tracking system, a GPS device, or signalemitting device that would allow for tracking of the position and/ororientation (non-limiting example: emplacement) of the tracking sensor(also referred to as an emplacement sensor). In some embodiments, aposition sensing unit 506 can be affixed to either or both of themedical devices 512, 514. The medical devices 512 or 514 can be trackedby the position sensing unit 506. A room coordinate system reference,such as the display 502 can also be tracked by the position sensing unit506 in order to determine the emplacements of the medical devices 512,514 with respect to the room coordinate system. Devices 512, 514 canalso include or have coupled thereto one or more accelerometers, whichcan be used to estimate movement, position, and location of the devices.In some embodiments, the position sensing unit 506 can be an AscensionFlock of Birds, Nest of Birds, driveBAY, medSAFE, trakSTAR, miniBIRD,MotionSTAR, pciBIRD, or Calypso 6D Localization System and trackingsensors attached to the first and/or second medical devices 512, 514 canbe magnetic tracking coils.

The term “tracking sensor” (also referred to as an emplacement sensor),as used herein, is a broad term encompassing its plain and ordinarymeaning and includes without limitation all types of magnetic coils orother magnetic field sensing devices for use with magnetic trackers,fiducials or other optically detectable markers for use with opticaltrackers, such as those discussed above and below, or other sensors,such as accelerometers, gyroscopes, etc. In some embodiments, thetracking sensors can be implemented using optical position sensingdevices, such as the HiBall tracking system and the position sensingunit 506 can form part of the HiBall tracking system. Tracking sensorscan also include a GPS device or signal emitting device that allows fortracking of the position and/or orientation of the tracking sensor. Insome embodiments, a signal emitting device might include aradio-frequency identifier (RFID). In such embodiments, the positionsensing unit 506 can use the GPS coordinates of the tracking sensors orcan, for example, triangulate the radio frequency signal being emittedby the RFID associated with tracking sensors. The tracking systems canalso include one or more 3D mice.

In certain embodiments, the system 501 can register the location of thevolumetric medical image 300 to the position sensing region and/or thepatient 516. Accordingly, the system 501 can use the emplacement dataand registered volumetric medical image 300 to identify the location ofthe medical devices 512, 514, relative to the volumetric medical image300, as well as identify the emplacement of the medical devices 512, 514relative to the identified medical device approaches.

Furthermore, the system 501 can use the emplacement data associated withthe tracking sensors (non-limiting example: received from the trackingsensors or from the position sensing unit 506) to determine otheremplacement information, including, but not limited to the emplacementof the medical device approaches as described above. In some cases, thetracking sensors can output the emplacement data, which can be used bythe tracker to determine the emplacement of the tracking sensor. Incertain cases, the tracker tracking the tracker sensors determines theemplacement of the tracking sensors without data being output from thetracking sensors.

In some embodiments, the display 502 displays 3D images to a user, suchas a healthcare provider. Stereoscopic 3D displays separate the imageryshown to each of the user's eyes. This can be accomplished by astereoscopic display, a lenticular auto-stereoscopic display, or anyother appropriate type of display. The display 502 can be an alternatingrow or alternating column display. Example alternating row displaysinclude the Miracube G240S, as well as Zalman Trimon Monitors.Alternating column displays include devices manufactured by Sharp, aswell as many “auto-stereoscopic” displays (non-limiting example:Philips). In some embodiments, Sony Panasonic 3D passive displays andLG, Samsung, and/or Vizio 3D TVs can be used as well. Display 502 canalso be a cathode ray tube. Cathode Ray Tube (CRT) based devices, canuse temporal sequencing, showing imagery for the left and right eye intemporal sequential alternation. This method can also be used byprojection-based devices, as well as by liquid crystal display (LCD)devices, light emitting diode (LED) devices, organic LED (OLED) devices,liquid crystal on silicon (LCOS) devices, DLP devices, virtual retinaldisplay (MicroVision) devices, or the like.

In certain embodiments, the display 502 can be a head mounted display(HMD) worn by the user in order to receive 3D images from the imageguidance unit 504. In such embodiments, a separate display, such as thepictured display 502, can be omitted. The 3D graphics can be producedusing underlying data models, stored in the image guidance unit 504 andprojected onto one or more 6D planes in order to create left and righteye images for a head mount, lenticular, or other 3D display.

The underlying 3D model can be updated based on the relativeemplacements of the various devices 512 and 514, as determined by theposition sensing unit(s) 506, and/or based on new data associated withthe devices 512 and 514. For example, if the second medical device 514is an ultrasound probe, then the underlying data model can be updated toreflect the most recent ultrasound image. If the first medical device512 is an ablation needle, then the underlying model can be updated toreflect any changes related to the needle, such as power or durationinformation.

Any appropriate 3D graphics processing can be used for renderingincluding processing based on OpenGL, Direct3D, Java 3D, etc. Whole,partial, or modified 3D graphics packages can also be used, suchpackages including 3DS Max, SolidWorks, Maya, Form Z, Cybermotion 3D,VTK, Slicer, or any others. In some embodiments, various parts of theneeded rendering can occur on traditional or specialized graphicshardware. The rendering can also occur on the general CPU, onprogrammable hardware, on a separate processor, be distributed overmultiple processors, over multiple dedicated graphics cards, or usingany other appropriate combination of hardware or technique.

One or more components, units, devices, or elements of variousembodiments can be packaged and/or distributed as part of a kit. Forexample, in one embodiment, an ablation needle, one or more trackingsensors, 3D viewing glasses, and/or a portion of an ultrasound wand canform a kit. Other embodiments can have different elements orcombinations of elements grouped and/or packaged together. Kits can besold or distributed separately from or with the other portions of thesystem 501.

One will readily recognize that there are numerous other examples ofimage guidance systems 501 which can use, incorporate, support, orprovide for the techniques, methods, processes, and systems describedherein.

With continued reference to FIG. 5A, the display 502 shows a perspectiveview of the volumetric medical image 300, a virtual ultrasound probe316, and a virtual needle 314. The virtual medical devices 314, 316 canbe displayed in a virtual 3D scene with the display 502 acting as awindow into the virtual 3D scene. Thus, as a medical device 512 is movedto the right with respect to a point-of-view location (non-limitingexample: the location of the point-of-view for viewing the 3D space),the virtual medical device 558 can also move to the right. In someembodiments, the virtual medical devices 314, 316 can correspond todetermined medical device emplacements for the medical devices 512, 514.For example, the virtual medical devices 314, 316 can indicate where themedical devices 512, 514 are to be emplaced. In such embodiments, thedisplay 502 can include additional virtual medical devices indicatingthe determined location of the medical devices 512, 514 relative to therecommended emplacements. Additional cues can be displayed to aid theuser in emplacing the medical devices in the recommended emplacements.

In some embodiments, if the medical device 512 is rotated 90° so thatthe tip of the medical device is pointing away from the point-of-viewlocation (non-limiting example: at the display 502), the virtual medicaldevice 558 will likewise show the change in orientation, and show thetip of the virtual medical device 558 in the background and the otherend of the virtual medical device 558 in the foreground. In someembodiments, as described in greater detail in U.S. application Ser. No.14/212,933, incorporated herein by reference in its entirety, thepoint-of-view location can be a fixed location, such as a predetermineddistance/angle from the display 502 or stand 518 and or a locationconfigured by the user; or the point-of-view location can by dynamic.For example, the system 501 can track a user in real-time and determinethe point-of-view location based at least in part on the trackedlocation of the user.

Other embodiments can track and display other types of instruments andtheir features. For example, a healthcare provider may want to track oneor more of a scalpel, a biopsy, a cauterizer (including anelectrocauterizer and Bovies), forceps, cutting loops on hysteroscopes,harmonic shears, lasers (including CO2 lasers), etc. For example, invarious embodiments, the following devices can be tracked and variousaspects of their design displayed on display 502: Olympus™ OES ProHystero-Resectoscope, SonoSurg Ultrasonic Surgical System Olympus™ GF-UC560 Endoscope Wallus™ Embryo Transfer Catheter AngioDynamics®NanoKnife™, VenaCure™ laser, StarBurst, Uniblade, Habib® Resector Bovie™Electrodes, Covidien Evident™, Cool-tip™ Ablation Antennas, Opti4™Electrodes Microsulis MEA (microwave endometrial ablation), AcculisHalt™ Medical System Optimed BigLumen Aspiration Catheter OptimedOptipure Stent Central venous catheterization introducer medical device(such as those made by Bard and Arrow).

Once tracked, a healthcare provider is able to see image guidance dataon display 502 that will allow her to know the relative pose, location,or emplacement of the tracked instrument(s) with respect to one anotheror with respect to imaging data and will be able to see, on display 620,the features of the instrument rendered in the scene.

Referring now to FIG. 5B, virtual image content may be displayed on ahead mounted display (HMD) 650 instead of or in addition to a display502 as depicted in FIG. 5A. The HMD 650 may include one or morestereoscopic displays 652, 654 configured to display 3D content to awearer of the HMD 650. For example, the HMD 650 can include a leftstereoscopic display 652 configured to project visual content 653 to aleft eye of a wearer, and a right stereoscopic display 654 configured todisplay visual content 655 to a right eye of a wearer. In someembodiments, displays 652, 654 can be opaque, and can be sized andlocated so as to occupy a subset of the field of view of a wearer. Incertain embodiments, the displays 652, 654 can be transparent ortranslucent, or can be implemented as retinal scan displays that projectan image onto the eye rather than display an image on the displayscreen.

Displays 652, 654 can allow the displayed content 653, 655 to be seenclearly without glare or interference due to light from the world in theregion beyond the displays 652, 654. In certain embodiments, displays652, 654 occupying less than the entire field of view of the wearer canallow the wearer to view the virtual content 653, 655 while also viewingthe real environment in the portion of the wearer's field of viewunoccupied by displays 652, 654, such as through transparent portions656, 658 of the HMD 650.

In some embodiments, the imaging systems described herein can displayvirtual image content on the displays 652, 654 using a location offsetwith respect to the location of corresponding objects. For example,rather than displaying and/or augmenting content that is directly infront of the displays 652, 654 and/or the HMD 650, the displays 652, 654can display and/or augment objects that are located elsewhere, such asbelow, above, or to the side of the displays 652, 654 and/or the HMD650. In the illustrated embodiment, the virtual medical devices 314, 316can be displayed with a vertical offset relative to the medical devices512, 514 so as to allow a wearer of the HMD 650, such as a surgeon, tosimultaneously view the virtual medical devices 558, 560 on the displays652, 654 and the patient 516 with real medical devices 512, 514 locatedbelow the HMD 650.

The offset can be predetermined based on a dimension or preference of anindividual wearer prior to use, or based on a default such as an averageheight or dimension of an expected wearer, or dynamic based on datareceived during use. An example offset can be a distance equal orapproximately equal to the vertical distance between a wearer's elbowand the wearer's eye (non-limiting example: in the range of 0.5 m to 5m), a measured distance between the HMD 650 and the medical devices 512,514, etc. Additional details regarding the offset are described in U.S.App. No. TBD, filed concurrently herewith, entitled, LOUPE DISPLAY(Attorney Docket: INOPT.061A).

The HMD 650 can be implemented with any of the imaging systems describedwith reference to FIG. 5A. For example, displays 652, 654 can displayvirtual medical devices 558, 560 corresponding to real medical devices512, 514. Displays 652, 654 can further display any other virtual imagefeatures described elsewhere herein, such as a medical device approach.

The processes, computer readable medium, and systems described hereincan be performed on various types of hardware, such as computer systemsor computing devices. In some embodiments, position sensing units, adisplay unit, image guidance units, and/or any other module or unit ofembodiments herein can each be separate computing devices, applications,or processes or can run as part of the same computing devices,applications, or processes—or one of more can be combined to run as partof one application or process—and/or each or one or more can be part ofor run on a computing device. Computing devices or computer systems caninclude a bus or other communication mechanism for communicatinginformation, and a processor coupled with the bus for processinginformation. A computer system or device can have a main memory, such asa random access memory or other dynamic storage device, coupled to thebus. The main memory can be used to store instructions and temporaryvariables. The computer system or device can also include a read-onlymemory or other static storage device coupled to the bus for storingstatic information and instructions. The computer systems or devices canalso be coupled to a display, such as a CRT, LCD monitor, LED array,e-paper, projector, or stereoscopic display. Input devices can also becoupled to the computer system or device. These input devices caninclude a mouse, a trackball, touchscreen, tablet, foot pedal, or cursordirection keys.

Each computer system or computing device can be implemented using one ormore physical computers, processors, embedded devices, fieldprogrammable gate arrays (FPGAs), or computer systems or portionsthereof. The instructions executed by the computer system or computingdevice can also be read from a computer-readable medium. Thecomputer-readable medium can be non-transitory, such as a CD, DVD,optical or magnetic disk, laserdisc, flash memory, or any other mediumthat is readable by the computer system or device. In some embodiments,hardwired circuitry can be used in place of or in combination withsoftware instructions executed by the processor. Communication amongmodules, systems, devices, and elements can be over a direct or switchedconnections, and wired or wireless networks or connections, via directlyconnected wires, or any other appropriate communication mechanism.Transmission of information can be performed on the hardware layer usingany appropriate system, device, or protocol, including those related toor utilizing Firewire, PCI, PCI express, CardBus, USB, CAN, SCSI, IDA,RS232, RS422, RS485, 802.11, etc. The communication among modules,systems, devices, and elements can include handshaking, notifications,coordination, encapsulation, encryption, headers, such as routing orerror detecting headers, or any other appropriate communication protocolor attribute. Communication can also messages related to HTTP, HTTPS,FTP, TCP, IP, ebMS OASIS/ebXML, DICOM, DICOS, secure sockets, VPN,encrypted or unencrypted pipes, MIME, SMTP, MIME Multipart/RelatedContent-type, SQL, etc.

Any appropriate 3D graphics processing can be used for displaying orrendering, including processing based on OpenGL, Direct3D, Java 3D, etc.Whole, partial, or modified 3D graphics packages can also be used, suchpackages including 3DS Max, SolidWorks, Maya, Form Z, Cybermotion 3D,VTK, Slicer, or any others. In some embodiments, various parts of theneeded rendering can occur on traditional or specialized graphicshardware. The rendering can also occur on the general CPU, onprogrammable hardware, on a separate processor, be distributed overmultiple processors, over multiple dedicated graphics cards, or usingany other appropriate combination of hardware or technique.

As will be apparent, the features and attributes of the specificembodiments disclosed above can be combined in different ways to formadditional embodiments, all of which fall within the scope of thepresent disclosure.

Conditional language used herein, such as, among others, “can,” “could,”“might,” “can,” “e.g.,” and the like, unless specifically statedotherwise, or otherwise understood within the context as used, isgenerally intended to convey that certain embodiments include, whileother embodiments do not include, certain features, elements and/orstates. Thus, such conditional language is not generally intended toimply that features, elements and/or states are in any way required forone or more embodiments or that one or more embodiments necessarilyinclude logic for deciding, with or without author input or prompting,whether these features, elements and/or states are included or are to beperformed in any particular embodiment.

Any process descriptions, elements, or blocks in the processes, methods,and flow diagrams described herein and/or depicted in the attachedfigures should be understood as potentially representing modules,segments, or portions of code which include one or more executableinstructions for implementing specific logical functions or steps in theprocess. Alternate implementations are included within the scope of theembodiments described herein in which elements or functions can bedeleted, executed out of order from that shown or discussed, includingsubstantially concurrently or in reverse order, depending on thefunctionality involved, as would be understood by those skilled in theart.

All of the methods and processes described above can be embodied in, andfully automated via, software code modules executed by one or moregeneral purpose computers or processors, such as those computer systemsdescribed above. The code modules can be stored in any type ofcomputer-readable medium or other computer storage device. Some or allof the methods can alternatively be embodied in specialized computerhardware.

It should be emphasized that many variations and modifications can bemade to the above-described embodiments, the elements of which are to beunderstood as being among other acceptable examples. All suchmodifications and variations are intended to be included herein withinthe scope of this disclosure and protected by the following claims.

1-18. (canceled)
 19. A system for medical device guidance, comprising: adisplay; and one or more processors configured to: obtain a volumetricmedical image, the volumetric medical image including a plurality ofimage slices; identify a target location within the volumetric medicalimage; determine a density of content within the volumetric medicalimage based at least in part on intensity values of voxels associatedwith the content within the volumetric medical image; identify a firstdirect pathway to the target location that does not pass through regionsof the volumetric medical image that satisfy a first density threshold;determine a suggested pose of a medical imaging device based at least inpart on the first direct pathway, wherein when the medical imagingdevice is placed at the suggested pose, a scan path of the medicalimaging device at least partially overlaps with the first directpathway; identify a second direct pathway to the target location thatdoes not pass through regions of the volumetric medical image thatsatisfy a second density threshold, wherein the regions that satisfy thesecond density threshold correspond to areas of the volumetric medicalimage that include an obstructing object, and wherein the second directpathway corresponds to a potential entry point into tissue of a patient;determine a suggested pose of a medical device based at least in part onthe second direct pathway; and cause the display to concurrentlydisplay: at least part of the volumetric medical image, an indication ofthe suggested pose for the medical imaging device, and an indication ofthe suggested pose for the medical device.
 20. The system of claim 19,wherein the second direct pathway passes through at least two of theplurality of image slices.
 21. The system of claim 19, wherein toidentify the target location within the volumetric medical image the oneor more processors is configured to: receive an indication of the targetlocation within the volumetric medical image; and determine the targetlocation within the volumetric medical image based at least in part onthe received indication.
 22. The system of claim 19, wherein the one ormore processors is configured to identify the target location within thevolumetric medical image based at least in part on an amount of timethat the medical device is located at a particular location.
 23. Thesystem of claim 19, wherein the second density threshold is based atleast in part on one or more characteristics of the medical imagingdevice, wherein the one or more characteristics of the medical imagingdevice comprises one or more of a number of imaging sensors of themedical imaging device, a number of transducer crystals of the medicalimaging device, an imaging depth of the medical imaging device, aresolution of the medical imaging device, a fade of the medical imagingdevice, an imaging width of the medical imaging device, an imagingthickness of the medical imaging device, a scan frequency of the medicalimaging device, or a type of the medical imaging device.
 24. The systemof claim 19, wherein the one or more processors is configured toidentify the first direct pathway based at least in part on a scan depthof the medical imaging device.
 25. The system of claim 19, wherein toidentify the second direct pathway the one or more processors isconfigured to: capture a volume of voxels between the target locationand an entry point; map the volume of voxels to an image area; andidentify at least a portion of the image area in which an approachregion is visible.
 26. The system of claim 19, wherein the regions thatsatisfy the first density threshold correspond to areas of thevolumetric medical image that include a gas.
 27. The system of claim 19,wherein the regions that satisfy the first density threshold correspondto areas of the volumetric medical image that include a bone.
 28. Thesystem of claim 19, wherein the regions that satisfy the second densitythreshold correspond to areas of the volumetric medical image thatinclude a gas.
 29. The system of claim 19, wherein the regions thatsatisfy the second density threshold correspond to areas of thevolumetric medical image that include a bone.
 30. A method for medicaldevice guidance, the method comprising: obtaining a volumetric medicalimage, the volumetric medical image including a plurality of imageslices; identifying a target location within the volumetric medicalimage; determining a suggested pose for a medical imaging device basedat least in part on the volumetric medical image; identifying a directpathway to the target location that does not pass through regions of thevolumetric medical image that satisfy a density threshold, wherein thedensity threshold corresponds to intensity values of voxels associatedwith content within the volumetric medical image, and wherein theregions that satisfy the density threshold correspond to areas of thevolumetric medical image that include an obstructing object; determininga suggested pose for a medical device based at least in part on theidentified direct pathway; and causing a display to concurrentlydisplay: at least part of the volumetric medical image, an indication ofthe suggested pose for a medical imaging device, and an indication ofthe suggested pose for the medical device.
 31. The method of claim 30,further comprising identifying a second direct pathway to the targetlocation that does not pass through regions of the volumetric medicalimage that satisfy the density threshold, wherein determining thesuggested pose of the medical imaging device is based at least in parton the second direct pathway.
 32. The method of claim 31, wherein whenthe medical imaging device is placed at the suggested pose, a scan pathof the medical imaging device at least partially overlaps with thesecond direct pathway.
 33. The method of claim 31, wherein identifyingthe second direct pathway further comprises: capturing a volume ofvoxels between the target location and an entry point; mapping thevolume of voxels to an image area; and identifying at least a portion ofthe image area in which an approach region is visible.
 34. The method ofclaim 30, wherein identifying the direct pathway is based at least inpart on a scan depth of the medical imaging device.
 35. The method ofclaim 30, wherein the density threshold is based at least in part on oneor more characteristics of the medical imaging device, wherein the oneor more characteristics of the medical imaging device comprises one ormore of a number of imaging sensors of the medical imaging device, anumber of transducer crystals of the medical imaging device, an imagingdepth of the medical imaging device, a resolution of the medical imagingdevice, a fade of the medical imaging device, an imaging width of themedical imaging device, an imaging thickness of the medical imagingdevice, a scan frequency of the medical imaging device, or a type of themedical imaging device.
 36. The method of claim 30, wherein the regionsthat satisfy the density threshold correspond to areas of the volumetricmedical image that include a gas.
 37. The method of claim 30, whereinthe regions that satisfy the density threshold correspond to areas ofthe volumetric medical image that include a bone.